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The Trypanosoma brucei U2 snRNA gene is transcribed by an RNA polymerase III-like enzyme and its promoter consists of one intragenic and two extragenic elements resembling tRNA gene A and B boxes.
The trypanosome U2 snRNA gene is uniquely transcribed by an RNA polymerase III-like enzyme and controlled by tRNA-like A and B box promoter elements.
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Unique T. brucei U2 snRNA transcription; leaves open conservation in eukaryotes and selective antiparasitic targeting.
Fantoni et al. (1994) studied this question. Transient DNA expression of mutant constructs was evaluated on Mapping of promoter elements of the Trypanosoma brucei U2 snRNA gene. The Trypanosoma brucei U2 snRNA gene is transcribed by an RNA polymerase III-like enzyme and its promoter consists of one intragenic and two extragenic elements resembling tRNA gene A and B boxes.