Key result
Dual inoculation of young chicks with chicken anaemia agent and virulent Marek's disease virus resulted in early mortality, severe necrosis, lymphoid depletion, and bone marrow aplasia.
Population
Young layer chicken flocks vaccinated with turkey herpesvirus at hatching, and young chicks used for…
Design
Preclinical
Authors
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Alerts to heightened mortality risk from dual viral exposure in chicks; leaves open relevance to other species or models.
Dual infection with chicken anaemia agent and Marek's disease virus induces an early mortality syndrome with severe lymphoid depletion in chicks.
Otaki et al. (1987) studied Disease characterized by high mortality, necrotic lesions, and lymphoid depletion. Dual inoculation with chicken anaemia agent (CAA82-2) and virulent Marek's disease virus (Md82-2) was evaluated on Early mortality associated with severe necrosis, lymphocyte depletion, and bone marrow aplasia. Dual inoculation of young chicks with chicken anaemia agent and virulent Marek's disease virus resulted in early mortality, severe necrosis, lymphoid depletion, and bone marrow aplasia.
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