What question did this study set out to answer?

The study aims to investigate the course of infection in tissues of susceptible chickens after exposure to various strains of Marek's disease virus and turkey herpesvirus.

June 16, 2026JNCI Journal of the National Cancer Institute

Course of Infection in Tissues of Susceptible Chickens After Exposure to Strains of Marek's Disease Virus and Turkey Herpesvirus

Q: What is the clinical evidence from this study?

Study design: Other. Population: Marek's disease virus and turkey herpesvirus infection. Intervention: Exposure to strains of Marek's disease virus and turkey herpesvirus vs. Comparisons between different viral strains. Primary outcome: Level of infectious virus in tissues and transmission by contact exposure.

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Key result

Virulent HPRS-16 Marek's disease virus yields higher infectious tissue levels than HVT and attenuated strains.

Population

Highly susceptible chickens

Comparison

Virulent MDV (HPRS 16), avirulent MDV (HPRS-27), attenuated MDV (HPRS-16), and turkey herpesvirus (HVT)

Design

Animal experimental study

Follow-up

About 60 days

Authors

PPP. A. Phillips PBP. M. Biggs

Discussion

Member takes

Implication

Attenuated strains' lack of contact spread may favor vaccination use in poultry; leaves open field efficacy trials.

Key Points

The study aims to investigate the course of infection in tissues of susceptible chickens after exposure to various strains of Marek's disease virus and turkey herpesvirus.
Chickens were inoculated or exposed via contact to virulent and avirulent strains of Marek's disease virus and turkey herpesvirus.
Infection was monitored across lung, spleen, and liver tissues over approximately 60 days.
Levels of cell-associated infectivity were measured and compared between different virus strains.
Virus was detected in lung and lymphoid tissues as early as 1 day post-inoculation.
Chickens infected with the HPRS-16 strain showed significantly higher levels of infectivity compared to those infected with HVT, HPRS-27, and attenuated HPRS-16.
No transmission of attenuated HPRS-16 and HVT was noted through contact exposure, unlike the apathogenic strain of MDV.

Structured PICO

Population

Highly susceptible chickens exposed to virulent, avirulent, and attenuated strains of Marek's disease virus and turkey herpesvirus, followed for about 60 days.

Intervention

Exposure by inoculation or contact with virulent (HPRS 16) and avirulent (HPRS-27) and attenuated (HPRS-16) strains of Marek's disease virus (MDV) and turkey herpesvirus (HVT)

Comparator

Comparisons between different viral strains (HPRS-16 vs HVT, HPRS-27, and attenuated HPRS-16)

Outcome

Level of cell-associated infectivity in tissues (lung, spleen, and liver)surrogate

Virulent Marek's disease virus produces significantly higher levels of cell-associated infectivity in chicken tissues compared to avirulent or attenuated strains and turkey herpesvirus.

Cite This Study

Phillips et al. (1972) studied Marek's disease virus and turkey herpesvirus infection. Exposure to strains of Marek's disease virus and turkey herpesvirus vs. Comparisons between different viral strains was evaluated on Level of infectious virus in tissues and transmission by contact exposure. Infection with the virulent HPRS-16 strain of Marek's disease virus produced significantly higher levels of infectious virus in most tissues compared to HVT, HPRS-27, and attenuated HPRS-16 strains.

synapsesocial.com/papers/6a31572eaf7cf7f8256b3df0 https://doi.org/10.1093/jnci/49.5.1367

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Course of Infection in Tissues of Susceptible Chickens After Exposure to Strains of Marek's Disease Virus and Turkey Herpesvirus

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Course of Infection in Tissues of Susceptible Chickens After Exposure to Strains of Marek's Disease Virus and Turkey Herpesvirus

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider