February 1, 1971Infection and ImmunityOpen Access

Pathogenicity and Antigenicity of Clones from Strains of Marek's Disease Virus and the Herpesvirus of Turkeys

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Population

Chicken embryo fibroblast cultures infected with JM, high passage JM, GA, and RPL39 strains of Marek's…

Design

Preclinical

Authors

HPH. G. PurchaseUniversity of Toledo Medical Center BBB. R. BurmesterPoultry Research Institute CCCharles H. CunninghamSunnybrook Health Science Centre

Discussion

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Implication

JMHP and HVT merit evaluation as potential MDV vaccines in poultry; leaves open mechanisms of independent viral trait changes in animal models.

Structured PICO

Population

Chicken embryo fibroblast cultures infected with JM, high passage JM (JMHP), GA, and RPL39 strains of Marek's disease virus (MDV) and herpesvirus of turkeys (HVT), and chickens for pathogenicity testing

Intervention

Cloning of virus strains

Outcome

Plaque morphology, pathogenicity for chickens, and antigenicity (A and B precipitin antigens, indirect fluorescent antibody test)surrogate

The study demonstrates that in Marek's disease virus and herpesvirus of turkeys, changes in virus-host cell relationships, loss of pathogenicity, and loss of A antigens are independent events.

Cite This Study

Purchase et al. (1971) studied this question.

synapsesocial.com/papers/6a83f812a3cef8348e997c91 https://doi.org/10.1128/iai.3.2.295-303.1971

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Implication

JMHP and HVT merit evaluation as potential MDV vaccines in poultry; leaves open mechanisms of independent viral trait changes in animal models.

Pathogenicity and Antigenicity of Clones from Strains of Marek's Disease Virus and the Herpesvirus of Turkeys

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pathogenicity and Antigenicity of Clones from Strains of Marek's Disease Virus and the Herpesvirus of Turkeys

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider