Key result
Clones R2/23 and R2/29 provided protection against very virulent Marek's disease virus strains superior to turkey herpesvirus and comparable to a bivalent vaccine (P>0.05).
Population
Susceptible antibody-negative chickens
Comparison
Attenuated revertant serotype 1 Marek's disease… vs Turkey herpesvirus vaccine and bivalent vaccine
Design
Preclinical
Authors
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Supports advancing R2/23 as Marek's vaccine candidate in poultry; hypothesis-generating pending field validation.
p-value: p=>0.05
Clone R2/23 of the revertant serotype 1 Marek's disease virus provides a safe and effective vaccine candidate for chickens.
R. L. Witter (1991) studied Marek's disease. Clones R2/23 and R2/29 (attenuated revertant serotype 1 Marek's disease viruses) vs. Turkey herpesvirus (HVT) and bivalent (HVT + SB-1) vaccine was evaluated on Protection against challenge with very virulent MDV strains (p=>0.05). Clones R2/23 and R2/29 provided protection against very virulent Marek's disease virus strains superior to turkey herpesvirus and comparable to a bivalent vaccine (P>0.05).
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