Key result
Acute cardiorenal syndrome is primarily driven by systemic congestion and increased renal venous pressure, making the correction of hypervolemia the mainstay of therapy.
Acute cardiorenal syndrome is primarily driven by renal venous congestion rather than low cardiac output, making aggressive decongestion the mainstay of therapy.
Absence of a robust definition limits consistent diagnosis of acute cardiorenal syndrome; leaves open consensus criteria for future trials.
Cardiac and renal dysfunction often coexist, and one begets the other. The association is referred to as cardiorenal syndrome. One subtype, acute cardiorenal syndrome, is often described as a clinical scenario in which acute worsening of cardiac function leads to acute kidney injury. Though this definition covers the basic pathophysiologic framework, a robust clinical definition is still lacking. Acute cardiorenal syndrome is common and often leads to emergency room visits and hospitalization. Our understanding of the hemodynamic mechanisms of acute cardiorenal syndrome is advancing. Correction of hypervolemia is the mainstay of therapy.
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Thind et al. (2018) conducted a review in Acute cardiorenal syndrome. Acute cardiorenal syndrome is primarily driven by systemic congestion and increased renal venous pressure, making the correction of hypervolemia the mainstay of therapy.
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