Why the study?
Does an estrogen-containing oral contraceptive induce hypertension in a patient with prior adrenalectomy and hypophysectomy on fixed mineralocorticoid replacement?
Case Report (n=1)
Does an estrogen-containing oral contraceptive induce hypertension in a patient with prior adrenalectomy and hypophysectomy on fixed mineralocorticoid replacement?
Answers are grounded in this paper and cite their sources.
Estrogen-containing oral contraceptives can induce volume-related hypertension when acting synergistically with fixed mineralocorticoid replacement, even in the absence of adrenal glands.
The cause of oral-contraceptive-induced hypertension in certain susceptible subjects is obscure. We describe a woman who was receiving replacement doses of fludrocortisone acetate after adrenalectomy and hypophysectomy who developed high blood pressure while ingesting an estrogen-containing oral contraceptive. Renin substrate level was increased, but renin activity was suppressed and unresponsive to tilting. The patient developed a markedly exaggerated natriuresis when infused with saline. Both blood pressure and her responses to infused sodium and tilting normalized after discontinuance of the oral contraceptive medication. In this adrenalectomized patient, the estrogenic component of the pill acting synergistically with a fixed ("nonsuppressible") replacement dose of mineralocorticoid seems to have caused a volume-related hypertension.
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Marshall D. Lindheimer (1976) conducted a case report in Oral-contraceptive-induced hypertension (n=1). Estrogen-containing oral contraceptive vs. Discontinuance of oral contraceptive was evaluated on Blood pressure and responses to infused sodium and tilting.
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