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Clinical analysis reveals airway HDAC2 and HDAC8 levels correlate with steroid responsiveness in COPD, highlighting potential biomarkers for targeted treatment.
Extract Inhaled corticosteroids (ICS) are widely used in COPD management, although their efficacy varies across patients. In many cases, ICS often provide only modest improvement in lung function and quality of life [1]. Moreover, long-term ICS use is associated with adverse effects such as pneumonia, oral candidiasis and dysphonia [2]. A key challenge, therefore, is identifying reliable biomarkers that predict corticosteroid responsiveness in COPD.
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Papakonstantinou et al. (2026) studied this question.
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