Case study reveals reduced LYVE-1 expression across skin layers in necrotizing necrobiosis lipoidica, indicating impaired lymphatic drainage and disrupted tissue homeostasis.
Key Points
To evaluate the expression of the lymphatic vessel endothelial hyaluronan receptor LYVE-1 in skin tissue affected by necrotizing necrobiosis lipoidica.
Conducted a clinical observation and histological examination of skin sections from a patient with necrotizing necrobiosis lipoidica compared to healthy skin.
Assessed LYVE-1 receptor expression across epidermal prelymphatics and dermal lymphatic vessels using immunohistochemistry.
LYVE-1 expression was markedly reduced in the basal and spinous layers containing necrobiotically altered cells and in the lymphatic vessel endothelium of the papillary and deep dermis compared to healthy controls.
Histological analysis showed morphological disruption of epidermal prelymphatics, interstitial swelling, and lymphatic vessel dilatation in both the papillary and reticular dermis.