What does this research mean for the field?

In patients with myeloproliferative neoplasms, hospitalization for heart failure is associated with significantly increased risks of all-cause mortality and disease progression, and is predicted by specific cardiovascular and hematologic factors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify clinical risk factors for heart failure hospitalization and examine its association with disease progression and mortality in patients with myeloproliferative neoplasms.

August 30, 2026Cardio-OncologyOpen Access

Incidence, risk factors, and prognostic implications of hospitalizations for heart failure among patients with myeloproliferative neoplasms

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Authors

OLOrly Leiva SZSophia Zhou SSSteven SooUniversity of Kentucky

Discussion

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Implication

Retrospective cohort study reveals heart failure hospitalizations predict increased mortality and progression in myeloproliferative neoplasms, highlighting cardiovascular surveillance needs.

Key Points

To identify clinical risk factors for heart failure hospitalization and examine its association with disease progression and mortality in patients with myeloproliferative neoplasms.
Multicenter retrospective cohort study of 546 patients with myeloproliferative neoplasms (42.7% polycythemia vera, 34.8% essential thrombocythemia, 22.5% myelofibrosis) who had at least one echocardiogram and no prior heart failure.
Identified risk factors for heart failure hospitalization using backward stepwise logistic regression, and evaluated all-cause mortality and progression to secondary myelofibrosis or acute leukemia using multivariable Cox and competing-risk regression.
Heart failure hospitalization occurred in 85 patients and was independently predicted by older age, left ventricular hypertrophy, E/A ratio > 2, prior prosthetic valve, pulmonary artery pressure > 40 mmHg, and splenomegaly, while ruxolitinib use was protective.
Heart failure hospitalization was significantly associated with higher all-cause mortality (adjusted HR 1.64, 95% CI 1.16–2.32) and increased risk of hematologic disease progression (adjusted SHR 1.99, 95% CI 1.05–3.77).

Cite This Study

Leiva et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0a36c1a8fb52e79cefb https://doi.org/10.1186/s40959-026-00564-1

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Implication

Retrospective cohort study reveals heart failure hospitalizations predict increased mortality and progression in myeloproliferative neoplasms, highlighting cardiovascular surveillance needs.