Review demonstrates advances in active emollients for barrier dysfunction in dermatoses, indicating potential to reduce topical corticosteroid reliance.
Key Points
To review the evolution of emollients and active cosmeceutical ingredients targeting epidermal barrier dysfunction in inflammatory dermatological conditions.
Narrative evaluation of current paradigms in epidermal barrier biology, non-standardized xerosis management, and formulation science for cosmeceuticals.
Advanced formulations, designated as 'emollients plus' and 'immunolents', incorporate bioengineered active agents that provide anti-inflammatory, antioxidant, antimicrobial, and antipruritic activity while supporting the cutaneous microbiome.
Optimized epidermal barrier restoration reduces transepidermal water loss, enhances stratum corneum hydration, and confers a steroid-sparing effect that decreases reliance on topical corticosteroids.