What is the clinical evidence from this study?

Study design: Other. Population: High-fat-diet-induced hypercholesterolemia-associated diabetes. Intervention: Wodyetia bifurcata leaf extracts vs. Baseline. Primary outcome: Fasting blood glucose (52.8% decrease).

What does this research mean for the field?

Wodyetia bifurcata leaf extracts demonstrate significant antihyperglycaemic, antihypercholesterolemic, antioxidant, and tissue-protective effects in a high-fat-diet-induced diabetic rat model. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the phytochemical profile and pharmacological efficacy of Wodyetia bifurcata leaf extracts against high-fat-diet-induced hypercholesterolemia and diabetes in rats.

August 30, 2026Open Access

Phytochemical and Pharmacological Evaluation of Wodyetia Bifurcata Leaf Extracts in High-Fat-Diet-Induced Hypercholesterolemia-Associated Diabetes in Albino Rats

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Key result

Hydroethanolic W. bifurcata extract reduces fasting blood glucose ~53% in diabetic rats.

52.8% decrease

Population

Male Wistar albino rats with high-fat-diet (HFD)-induced hypercholesterolemia-associated diabetes

Design

Preclinical

Follow-up

28 days

Authors

RKRashmi Kumari LPL. Rajesh Patro

Discussion

Member takes

Implication

Wodyetia bifurcata leaf extracts demonstrated antihyperglycaemic and antihypercholesterolemic effects in a rat model of high-fat-diet-induced diabetes.

Key Points

To evaluate the phytochemical profile and pharmacological efficacy of Wodyetia bifurcata leaf extracts against high-fat-diet-induced hypercholesterolemia and diabetes in rats.
Prepared ethanolic and hydroethanolic extracts of authenticated W. bifurcata leaves to screen phytochemical constituents and quantify antioxidant capacity via DPPH assay.
Administered extracts orally for 28 days to male Wistar albino rats with high-fat-diet-induced metabolic dysfunction to measure blood glucose, lipid profiles, and hepatic/pancreatic histology.
Hydroethanolic extract showed higher total phenolics (21.83 ± 0.02 mg GAE/g) and flavonoids (28.76 ± 0.66 mg RE/g) than ethanolic extract, with a DPPH IC50 of 31.32 ± 0.046 µg/mL versus 10.35 ± 0.026 µg/mL for ascorbic acid.
Hydroethanolic extract at 120 mg/kg reduced fasting blood glucose from 310.75 ± 4.91 mg/dL to 129.25 ± 7.35 mg/dL at day 28 (a 52.8% decrease), while ethanolic extract improved lipid profiles.
Histopathological analysis showed marked structural preservation and recovery in both hepatic and pancreatic tissues following 28 days of extract treatment.

Structured PICO

Population

Male Wistar albino rats with high-fat-diet-induced hypercholesterolemia-associated diabetes treated with Wodyetia bifurcata leaf extracts for 28 days.

Intervention

Wodyetia bifurcata leaf extracts (ethanolic and hydroethanolic) administered orally at 120 mg/kg for 28 days

Outcome

Fasting blood glucose, serum lipid profile, urine glucose, body weight, and histopathology of liver and pancreassurrogate

Main Result

Effect estimate: 52.8% decrease

Absolute Event Rate: 129.25% vs 310.75%

Wodyetia bifurcata leaf extracts demonstrated antihyperglycaemic and antihypercholesterolemic effects in a rat model of high-fat-diet-induced diabetes.

Cite This Study

Kumari et al. (2026) studied High-fat-diet-induced hypercholesterolemia-associated diabetes. Wodyetia bifurcata leaf extracts vs. Baseline was evaluated on Fasting blood glucose (52.8% decrease). Hydroethanolic extract of W. bifurcata at 120 mg/kg reduced fasting blood glucose from 310.75 mg/dL at baseline to 129.25 mg/dL on day 28 in a diabetic rat model.

synapsesocial.com/papers/6a93f0c06c1a8fb52e79d352 https://doi.org/10.5281/zenodo.22138003

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Implication

Wodyetia bifurcata leaf extracts demonstrated antihyperglycaemic and antihypercholesterolemic effects in a rat model of high-fat-diet-induced diabetes.

Phytochemical and Pharmacological Evaluation of Wodyetia Bifurcata Leaf Extracts in High-Fat-Diet-Induced Hypercholesterolemia-Associated Diabetes in Albino Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Phytochemical and Pharmacological Evaluation of Wodyetia Bifurcata Leaf Extracts in High-Fat-Diet-Induced Hypercholesterolemia-Associated Diabetes in Albino Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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