What does this research mean for the field?

In hypoglycemic neonates, diazoxide treatment identifies a vulnerable, predominantly preterm subgroup with inadequate insulin suppression and is associated with a significantly increased risk of fluid retention. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Evaluate the clinical and hormonal characteristics and short-term outcomes associated with diazoxide use in neonates treated for hypoglycemia.

August 30, 2026ChildrenOpen Access

Clinical and Hormonal Characteristics and Short-Term Outcomes of Diazoxide Use in Hypoglycemic Neonates: A Retrospective Cohort Study

View Full Paper

Ask AI

Bookmark

Evaluate the clinical and hormonal characteristics and short-term outcomes associated with diazoxide use in neonates treated for hypoglycemia.
Single-center retrospective cohort study of 124 hypoglycemic neonates treated between January 2020 and January 2026, comparing 36 who received diazoxide with 88 who did not.
Critical hormonal samples were obtained at blood glucose < 47 mg/dL prior to diazoxide administration, with treatment determinants analyzed using multivariable and Firth-penalized logistic models.
Diazoxide-treated neonates demonstrated significantly higher insulin levels (median 6.05 vs. 2.77 mU/L; adjusted GMR 2.23, 95% CI 1.38–3.61; p = 0.001) and C-peptide levels (adjusted GMR 1.59, 95% CI 1.03–2.47; p = 0.038).
Infants receiving diazoxide were more frequently preterm (80.6% vs. 52.3%; p = 0.003), while the frequency of severe hypoglycemia (< 25 mg/dL) did not differ significantly between arms (27.8% vs. 17.0%; p = 0.176).
Fluid retention requiring diuretics was more frequent in the diazoxide arm (11/36 [30.6%] vs. 11/88 [12.5%]; p = 0.017), whereas pulmonary hypertension was not observed on day 5–7 echocardiography (0/36; exact 95% CI 0.0–9.7%).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Retrospective cohort study reveals higher insulin levels and increased fluid retention with diazoxide in hypoglycemic neonates, highlighting careful monitoring needs.

Cite This Study

Bali et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0ce6c1a8fb52e79d515 https://doi.org/10.3390/children13091157

View Full Paper

Ask AI

Bookmark

Implication

Retrospective cohort study reveals higher insulin levels and increased fluid retention with diazoxide in hypoglycemic neonates, highlighting careful monitoring needs.

Clinical and Hormonal Characteristics and Short-Term Outcomes of Diazoxide Use in Hypoglycemic Neonates: A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

Clinical and Hormonal Characteristics and Short-Term Outcomes of Diazoxide Use in Hypoglycemic Neonates: A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider