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August 30, 2026PLoS ONEOpen Access

Long-term effects of cognitive behavioural therapy on the quality of life in adult ADHD

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Authors

RWR. WettsteinVNValentina Navarro-OvandoVJViktoria Janke

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Overview

Follow-up study finds no added long-term quality of life benefit from cognitive behavioral therapy in adult ADHD, indicating that initial standard care drives sustained gains.

Key Points

  • To evaluate the long-term effects (4–8 years) of adding cognitive behavioural therapy to pharmacotherapy and psychoeducation on quality of life in adults with ADHD.
  • Follow-up study of 627 adults with ADHD from a prior cohort, with 159 participants completing the 4-to-8-year follow-up assessment.
  • Compared standard care (pharmacotherapy and psychoeducation) with or without adjunctive cognitive behavioural therapy (CBT).
  • Evaluated outcomes using the Adult ADHD Quality of Life scale (AAQoL) via linear mixed model analyses.
  • Linear mixed modeling showed no significant treatment effect or treatment-by-time interaction for total AAQoL or any subdomain, with no between-group difference in clinically meaningful improvements.
  • A significant effect of time was observed across all participants: AAQoL scores increased from baseline (pooled mean = 44.4; PsyEd: 46.4, PsyEd + CBT: 42.4) to post-treatment (69.3), then declined at follow-up (52.1) while remaining above baseline.

Cite This Study

Wettstein et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0ce6c1a8fb52e79d555https://doi.org/10.1371/journal.pone.0356825
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