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February 9, 2026Depression and Anxiety1 citationsOpen Access

Effects of Transdiagnostic Cognitive Behavioural Therapy on Long-Term Quality of Life

Effects of Transdiagnostic Cognitive Behavioural Therapy on Long‐Term Quality of Life: A Causal Mediation Analysis Across Anxiety and Depressive Symptoms

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Authors

GEGabriel Esteller-ColladoUniversitat de ValènciaMCMaría Carpallo-GonzálezUniversitat de ValènciaMPMaider Prieto-VilaUniversidad Complutense de Madrid

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Overview

Causal mediation analysis shows TD-CBT enhances quality of life in primary care patients with anxiety and depression, suggesting long-term benefits.

Key Points

  • This study aims to explore how changes in anxiety and depression symptoms mediate the long-term impact of TD-CBT on quality of life.
  • Analyzed data from the Psychology in Primary Care trial with 1061 primary care patients.
  • Participants were randomized to receive TD-CBT plus treatment-as-usual or treatment-as-usual alone.
  • Assessed anxiety and depression at multiple time points, including baseline and follow-ups.
  • Measured quality of life at baseline and at 12-month follow-up using path analysis.
  • Employed structural equation modelling to evaluate direct and indirect effects.
  • TD-CBT significantly decreased anxiety and depression compared to treatment-as-usual.
  • Improvement in quality of life after 12 months primarily occurred through reductions in depressive symptoms.
  • No significant mediation effect was found through anxiety symptoms.
  • Direct effects of treatment also contributed to long-term quality of life improvements.
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Cite This Study

Esteller-Collado et al. (2026) studied this question.

synapsesocial.com/papers/69897a86f0ec2af6756e8b64https://doi.org/10.1155/da/1601969
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