What does this research mean for the field?

Intensive care units are the highest-risk settings for healthcare-associated infections, which are increasingly complicated by multidrug-resistant pathogens but can be effectively mitigated through strict adherence to hand hygiene and comprehensive infection control programs. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To comprehensively synthesize evidence on the epidemiology of healthcare-associated infections and identify key challenges involving antimicrobial resistance and infection prevention and control.

August 30, 2026Reviews on Environmental Health

Healthcare-associated infections: epidemiology, antimicrobial resistance, and infection control challenges: a systematic review

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Authors

HNHamidreza NassehiniaUniversity of Neyshabur RSRosita SaeidiSemnan University of Medical Sciences FYFariba YaghoubiUniversity of Neyshabur

Discussion

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Implication

Systematic review reveals high multidrug resistance and intensive care vulnerability in healthcare-associated infections, highlighting hand hygiene and stewardship as vital control measures.

Key Points

To comprehensively synthesize evidence on the epidemiology of healthcare-associated infections and identify key challenges involving antimicrobial resistance and infection prevention and control.
Conducted a systematic review following PRISMA 2020 guidelines across published literature from 1980 to 2025.
Screened 190 records and evaluated study quality using the Newcastle-Ottawa Scale, including 43 high-quality studies (score ≥6) assessed independently by two reviewers.
Urinary tract infections, respiratory tract infections, bloodstream infections, and skin and soft tissue infections represent the most frequently reported healthcare-associated infections.
Intensive care units were identified as the highest-risk settings for pathogen transmission, driven substantially by the proliferation of multidrug-resistant microorganisms.
Adherence to standardized hand hygiene practices was consistently identified as one of the most effective interventions for reducing pathogen transmission and preventing healthcare-associated infections.

Cite This Study

Nassehinia et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0e06c1a8fb52e79d69f https://doi.org/10.1515/reveh-2026-0112

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Implication

Systematic review reveals high multidrug resistance and intensive care vulnerability in healthcare-associated infections, highlighting hand hygiene and stewardship as vital control measures.

Healthcare-associated infections: epidemiology, antimicrobial resistance, and infection control challenges: a systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

Healthcare-associated infections: epidemiology, antimicrobial resistance, and infection control challenges: a systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

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