Effectiveness of High-Dose versus Standard-Dose Influenza Vaccine against Venous Thromboembolic Events: A Post Hoc Analysis of the DANFLU-2 Trial

K Kader; Manan Pareek; Niklas Dyrby Johansen; Daniel Modin; Matthew M. Loiacono; Rebecca C. Harris; Marine Dufournet; Carsten Schade Larsen; Lykke Larsen; Lothar Wiese; Michael Dalager‐Pedersen; Brian L. Claggett; Kira Hyldekær Janstrup; Katja Vu Bartholdy; Katrine Feldballe Bernholm; Julie Inge-Marie Helene Borchsenius; Filip Soeskov Davidovski; Lise Witten Davodian; Maria Dons; Lisa Steen Duus; Caroline Espersen; Frederik Holme Fussing; Anne Marie Reimer Jensen; Nino Emanuel Landler; Adam Cadovius Femerling Langhoff; Mats Christian Højbjerg Lassen; Anne Bjerg Nielsen; Camilla Ikast Ottosen; Morten Sengeløv; Kristoffer Grundtvig Skaarup; Scott D. Solomon; Martin J Landray; Gunnar Gislason; Lars Køber; Pradeesh Sivapalan; Cyril Jean‐Marie Martel; Jens‐Ulrik Stæhr Jensen; Tor Biering‐Sørensen

doi:10.1093/eurjpc/zwag440

August 28, 2026European Journal of Preventive CardiologyOpen Access

Effectiveness of High-Dose versus Standard-Dose Influenza Vaccine against Venous Thromboembolic Events: A Post Hoc Analysis of the DANFLU-2 Trial

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Key Points

To assess the comparative effectiveness of high-dose versus standard-dose quadrivalent influenza vaccination in preventing venous thromboembolic events.
Conducted a post hoc secondary analysis of the randomized DANFLU-2 clinical trial.
Compared rates of venous thromboembolic outcomes between recipients of high-dose and standard-dose influenza vaccines during the influenza season.
Examined relative risk reductions for venous thromboembolism associated with high-dose compared to standard-dose influenza vaccination.

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Implication

Study post hoc analysis evaluates venous thromboembolic events with high-dose versus standard-dose influenza vaccination, suggesting potential protective vascular benefits.

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Kader et al. (2026) studied this question.

synapsesocial.com/papers/6a93f0f56c1a8fb52e79d818 https://doi.org/10.1093/eurjpc/zwag440

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Effectiveness of High-Dose versus Standard-Dose Influenza Vaccine against Venous Thromboembolic Events: A Post Hoc Analysis of the DANFLU-2 Trial

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Effectiveness of High-Dose versus Standard-Dose Influenza Vaccine against Venous Thromboembolic Events: A Post Hoc Analysis of the DANFLU-2 Trial

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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