Key result
CCTA detects severe LAD stenosis with ~80% sensitivity versus invasive coronary angiography.
Why the study?
Does coronary computed tomography angiography (CCTA) accurately diagnose >70% coronary stenosis compared to invasive coronary angiography in patients with coronary artery disease?
Cross-Sectional (n=52)
No
Does coronary computed tomography angiography (CCTA) accurately diagnose >70% coronary stenosis compared to invasive coronary angiography in patients with coronary artery disease?
CCTA demonstrates variable diagnostic performance for detecting >70% coronary stenosis compared to invasive angiography, with accuracy depending significantly on the specific coronary vessel evaluated.
Objective: This study aimed to describe the diagnostic value of coronary computed tomography angiography (CCTA) compared with invasive coronary angiography (ICA) in patients with coronary artery disease. Methods: A cross-sectional descriptive study was conducted using retrospective data. Non-probability sampling was applied, including all eligible patients who met the inclusion criteria during the study period from January 2022 to December 2024 at Hai Phong International General Hospital. Study Equipment: A 128-slice CT scanner (Revolution CT, GE Healthcare, USA) and a digital subtraction angiography (DSA) system for invasive coronary angiography (Philips, Netherlands) were utilized. Results: A total of 52 patients were included, with a mean age of 71.65 ± 9.5 years. For the diagnosis of >70% stenosis of the right coronary artery (RCA), CCTA demonstrated a sensitivity of 91.3% and a specificity of 24.1% (p = 0.379). For >70% stenosis of the left anterior descending artery (LAD), CCTA showed a sensitivity of 80% and a specificity of 63.6% (p = 0.001). For >70% stenosis of the left circumflex artery (LCx), CCTA yielded a sensitivity of 20.0% and a specificity of 89.1% (p = 0.005). Conclusion: CCTA is a non-invasive technique with shorter acquisition time and lower cost compared to invasive coronary angiography. Advances in CT technology have progressively improved diagnostic performance, thereby supporting more accurate and appropriate therapeutic decision-making.
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Hoang et al. (2026) conducted a cross-sectional in Coronary artery disease (n=52). Coronary computed tomography angiography (CCTA) vs. Invasive coronary angiography (ICA) was evaluated on Diagnosis of >70% stenosis of the left anterior descending artery (LAD) (Sensitivity 80%, Specificity 63.6%, p=0.001). Coronary computed tomography angiography demonstrated 80% sensitivity and 63.6% specificity for detecting >70% LAD stenosis (p=0.001) compared to invasive coronary angiography.
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