Key result
The Rous sarcoma virus direct repeat element promotes nucleocytoplasmic export of unspliced RNA via a novel CRM1-independent pathway that does not directly bind the cellular Tap protein.
Population
In vitro models studying Rous sarcoma virus (RSV) RNA export
Comparison
RSV direct repeat (DR) elements vs HIV-1 and simian retroviruses
Design
Preclinical
Authors
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Distinguishes RSV export from HIV-1 pathways; leaves open relevance to human retroviruses and therapeutic targets.
The RSV DR element utilizes a novel nucleocytoplasmic RNA export pathway distinct from those used by HIV-1 and simian retroviruses.
Paca et al. (2000) studied Rous Sarcoma Virus RNA export. RSV DR element vs. Mutant DR elements or no DR element was evaluated on Nucleocytoplasmic export of unspliced RNA. The Rous sarcoma virus direct repeat element promotes nucleocytoplasmic export of unspliced RNA via a novel CRM1-independent pathway that does not directly bind the cellular Tap protein.
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