Key result
Heparin therapy combined with aggressive caval interruption using a Modin-Uddin umbrella eliminated deaths in 450 cases, compared to a 1.7% mortality rate in an earlier cohort of 231 patients.
Why the study?
Does heparin therapy combined with caval interruption by Modin-Uddin umbrella prevent death from pulmonary embolism in patients after coronary artery surgery?
Population
Patients who underwent aortocoronary artery graft surgery (initial cohort n=231, subsequent cohort n=450)
Comparison
Heparin therapy and aggressive caval… vs Prior management including elastic stockings and…
Design
Cohort
Follow-up
1 year (for the initial cohort)
Authors
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Should not yet change practice for PE prevention after CABG; leaves open whether caval interruption adds benefit beyond heparin alone.
Observational (n=681)
Does heparin therapy combined with caval interruption by Modin-Uddin umbrella prevent death from pulmonary embolism in patients after coronary artery surgery?
Absolute Event Rate: 0% vs 1.7%
Aggressive caval interruption with a Modin-Uddin umbrella combined with heparin therapy eliminated mortality from pulmonary embolism following coronary artery bypass surgery in this cohort.
Rao et al. (1975) conducted an observational in Pulmonary embolism after aortocoronary artery graft surgery (n=681). Heparin therapy and aggressive caval interruption by Modin-Uddin umbrella vs. Standard care / historical controls was evaluated on Death. Heparin therapy combined with aggressive caval interruption using a Modin-Uddin umbrella eliminated deaths in 450 cases, compared to a 1.7% mortality rate in an earlier cohort of 231 patients.
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