Key result
Peri- and postoperative increases in S-100 protein and neuron-specific enolase significantly correlated with impaired neuropsychological performance at 6 months after cardiac surgery.
Why the study?
Do perioperative levels of S-100 protein and neuron-specific enolase correlate with the development of neuropsychological deficits 6 months after cardiac surgery?
Population
16 patients undergoing elective cardiac surgery with cardiopulmonary bypass
Design
Cohort
Follow-up
6 months
Authors
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May flag cognitive risk after cardiac surgery; hypothesis-generating and requires prospective validation before clinical use.
Observational (n=16)
Do perioperative levels of S-100 protein and neuron-specific enolase correlate with the development of neuropsychological deficits 6 months after cardiac surgery?
Elevated perioperative levels of S-100 and NSE may serve as early biomarkers for subclinical cerebral damage and subsequent cognitive impairment following cardiac surgery.
Basile et al. (2001) conducted an observational in Elective cardiac surgery with cardiopulmonary bypass (n=16). S-100 protein and neuron-specific enolase (NSE) levels was evaluated on Neuropsychological deficits at 6 months. Peri- and postoperative increases in S-100 protein and neuron-specific enolase significantly correlated with impaired neuropsychological performance at 6 months after cardiac surgery.
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