Key result
Hemolysis falsely increased neuron-specific enolase (NSE) plasma concentrations but did not interfere with S-100 protein determinations during coronary artery bypass grafting.
Why the study?
Does hemolysis affect the measurement of S-100β protein and neuron-specific enolase (NSE) plasma concentrations during CABG?
Observational (n=24)
Does hemolysis affect the measurement of S-100β protein and neuron-specific enolase (NSE) plasma concentrations during CABG?
S-100 protein may be a more accurate biological marker of cerebral injury than NSE during cardiovascular surgery because its measurement is not affected by hemolysis.
No takes yet. Share an insight, caveat, or question.
Hemolysis may compromise NSE reliability during CABG; supports S-100β preference but remains hypothesis-generating pending prospective validation.
Beaudeux et al. (2000) conducted an observational in Coronary artery bypass grafting (CABG) (n=24). Hemolysis vs. Moderate or no hemolysis was evaluated on Plasma concentrations of S-100 and NSE. Hemolysis falsely increased neuron-specific enolase (NSE) plasma concentrations but did not interfere with S-100 protein determinations during coronary artery bypass grafting.
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