Key result
Early postoperative NSAID administration was not significantly associated with acute kidney injury following major gastrointestinal surgery (adjusted OR 0.80; 95% CI 0.63-1.00; P=0.057).
Why the study?
Postoperative NSAID use is limited by concerns regarding increased risks of acute kidney injury and anastomotic leak, despite their analgesic, opioid-sparing, and anti-inflammatory benefits.
Does early postoperative NSAID administration increase the risk of acute kidney injury or anastomotic leak in patients undergoing major gastrointestinal surgery?
Population
5240 patients undergoing elective or emergency major gastrointestinal surgery across 173 hospitals
Comparison
Early postoperative NSAID administration vs no early postoperative NSAIDs
Design
Secondary analysis of a multicenter prospective cohort study
Follow-up
7-day postoperative
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No association seen with early NSAIDs and post-GI surgery AKI; hypothesis-generating and should not yet change practice.
Cohort (n=5,240)
Yes
Does early postoperative NSAID administration increase the risk of acute kidney injury or anastomotic leak in patients undergoing major gastrointestinal surgery?
Odds Ratio: 0.8 (95% CI 0.63–1)
Absolute Event Rate: 10.6% vs 14.9%
p-value: p=0.057
Early postoperative NSAID administration appears safe and is not significantly associated with an increased risk of acute kidney injury or anastomotic leak following major gastrointestinal surgery.
A 2020 study conducted a cohort in Major gastrointestinal surgery (n=5,240). Early postoperative NSAIDs vs. No NSAIDs was evaluated on 7-day postoperative AKI rate (adjusted OR 0.80, 95% CI 0.63-1.00, p=0.057). Early postoperative NSAID administration was not significantly associated with acute kidney injury following major gastrointestinal surgery (adjusted OR 0.80; 95% CI 0.63-1.00; P=0.057).
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