Key result
Compared to wild-type mice, Tg2576 Alzheimer model mice exhibited up to a 20% reduction in cerebrum 18F-FDG uptake and a significant 60% decrease in intrascapular brown adipose tissue uptake.
Why the study?
Does 18F-FDG PET imaging detect metabolic deficits in the brain and intrascapular brown adipose tissue of Tg2576 Alzheimer's disease mouse models compared to wild-type mice?
Population
Transgenic Tg2576 mice (model of β-amyloid plaques) and wild-type (WT) mice, >18 months old
Comparison
18F-fluoro-2-deoxyglucose positron emission… vs Wild-type (WT) mice
Design
Preclinical
Follow-up
60 minutes post-injection
Authors
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Animal data link 18F-FDG PET to systemic metabolic deficits in AD models; leaves open human translation and clinical utility.
Does 18F-FDG PET imaging detect metabolic deficits in the brain and intrascapular brown adipose tissue of Tg2576 Alzheimer's disease mouse models compared to wild-type mice?
18F-FDG PET imaging reveals significant metabolic deficits in the brain and intrascapular brown adipose tissue of Tg2576 Alzheimer's disease mouse models when accounting for blood glucose levels.
Coleman et al. (2017) studied Alzheimer disease. Transgenic Tg2576 genotype vs. Wild-type mice was evaluated on 18F-FDG uptake in brain and intrascapular brown adipose tissue. Compared to wild-type mice, Tg2576 Alzheimer model mice exhibited up to a 20% reduction in cerebrum 18F-FDG uptake and a significant 60% decrease in intrascapular brown adipose tissue uptake.
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