What question did this study set out to answer?

To determine whether behavioral disinhibition in 9-month-old Tg2576 Alzheimer's disease model mice stems from hyperlocomotion or hypothalamic-pituitary-adrenal axis dysregulation.

January 1, 2007Behavioral Neuroscience

Increase of locomotor activity underlying the behavioral disinhibition in Tg2576 mice.

View Full Paper

Ask AI

Bookmark

Authors

FGFrancisco J. Gil‐BeaIkerbasque BABárbara AisaNavarre Institute of Health Research RSReinhard SchliebsAllen Institute for Brain Science

Discussion

Member takes

Implication

Animal study reveals increased locomotion underlies behavioral disinhibition in 9-month-old Tg2576 mice, suggesting general hyperactivity rather than endocrine stress system dysfunction.

Key Points

To determine whether behavioral disinhibition in 9-month-old Tg2576 Alzheimer's disease model mice stems from hyperlocomotion or hypothalamic-pituitary-adrenal axis dysregulation.
Evaluated 9-month-old transgenic Tg2576 mice and wild-type control mice.
Assessed behavior using open-field locomotor activity tests, open-arm exploration tasks, and the forced swimming test.
Quantified hypothalamic-pituitary-adrenal axis parameters, including adrenal gland weight, plasma corticosterone levels, and adrenaline and noradrenaline release.
Tg2576 mice moved almost twice as much as controls and spent significantly more time visiting open arms, with open-arm entries correlating positively with locomotor activity.
Tg2576 mice demonstrated a significant decrease in immobility duration during the forced swimming test, which correlated negatively with locomotor activity.
Plasma corticosterone levels, adrenal gland weights, and adrenaline or noradrenaline release showed no significant differences between Tg2576 mice and controls.

Cite This Study

Gil‐Bea et al. (2007) studied this question.

synapsesocial.com/papers/6aa413d2ef148610eb1ab762 https://doi.org/10.1037/0735-7044.121.2.340

View Full Paper

Ask AI

Bookmark

Implication

Animal study reveals increased locomotion underlies behavioral disinhibition in 9-month-old Tg2576 mice, suggesting general hyperactivity rather than endocrine stress system dysfunction.

Increase of locomotor activity underlying the behavioral disinhibition in Tg2576 mice.

Discussion

Member takes

Implication

Key Points

Cite This Study

Increase of locomotor activity underlying the behavioral disinhibition in Tg2576 mice.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider