Key result
Feline calicivirus field isolates showed different reactivities with monoclonal antibodies in ELISA compared to neutralization tests, suggesting neutralizing epitopes may be expressed on non-infectious particles.
Population
Feline calicivirus field isolates and laboratory strains propagated in Crandell feline kidney cells
Comparison
Enzyme-linked immunosorbent assay using 12… vs Neutralization tests (NT) from a previous study
Design
Preclinical
Authors
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Alerts to assay discordance in FCV studies; leaves open functional role of non-infectious particles for vaccine research.
The reactivities of feline calicivirus field isolates with monoclonal antibodies in ELISA differ from those in neutralization tests, suggesting neutralizing epitopes may be expressed on non-infectious particles.
Tajima et al. (1998) studied Feline calicivirus. Enzyme-Linked Immunosorbent Assay (ELISA) with monoclonal antibodies vs. Neutralization tests (NT) was evaluated on Reactivity of FCV field isolates with monoclonal antibodies. Feline calicivirus field isolates showed different reactivities with monoclonal antibodies in ELISA compared to neutralization tests, suggesting neutralizing epitopes may be expressed on non-infectious particles.
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