What question did this study set out to answer?

Characterize familial hypocalciuric hypercalcemia to clarify its clinical presentation and distinguish its underlying mineral regulation from other forms of chronic hypercalcemia.

August 12, 1982New England Journal of Medicine

Familial Hypocalciuric Hypercalcemia

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Characterize familial hypocalciuric hypercalcemia to clarify its clinical presentation and distinguish its underlying mineral regulation from other forms of chronic hypercalcemia.
Evaluated kindreds with familial benign hypercalcemia across multiple generations, including follow-up on previously reported cohorts and two additional large families.
Measured urinary calcium excretion alongside serum concentrations of calcium and magnesium in affected and unaffected family members.
Hypercalcemic individuals across the investigated families consistently exhibited low urinary calcium excretion (hypocalciuria) without substantial morbidity.
Identified an inherited disorder of calcium and magnesium homeostasis that remains frequently undiagnosed despite a relatively common occurrence.

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Implication

Family study uncovers benign hypercalcemia with hypocalciuria in affected kindreds, highlighting unique disturbances in mineral regulation.

Cite This Study

Bleich et al. (1982) studied this question.

synapsesocial.com/papers/6a93f73a0533089f4392cc60 https://doi.org/10.1056/nejm198208123070707

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Implication

Family study uncovers benign hypercalcemia with hypocalciuria in affected kindreds, highlighting unique disturbances in mineral regulation.

Familial Hypocalciuric Hypercalcemia

Key Points

Discussion

Implication

Cite This Study

Familial Hypocalciuric Hypercalcemia

Key Points

Discussion

Implication

Cite This Study

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