Key result
FGF signaling via Mek1/2 is dominant over BMP signaling via Smad and is required to separate the epicardial lineage from precardiac mesoderm during heart development.
FGF and BMP signaling pathways regulate the lineage separation of epicardium and myocardium from a common precursor pool, providing developmental insights that could inform future regenerative therapies for heart disease.
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Remains preclinical without therapeutic implications; leaves open FGF-Mek1/2 targeting for future regenerative cardiac therapies.
Wijk et al. (2009) studied Heart development. FGF and BMP signaling manipulation was evaluated on Lineage separation of myocardial and (pro)epicardial cells. FGF signaling via Mek1/2 is dominant over BMP signaling via Smad and is required to separate the epicardial lineage from precardiac mesoderm during heart development.
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