What question did this study set out to answer?

To evaluate cyclical patterns of gonadotrophin and sex steroid secretion in women with a history of recurrent early pregnancy loss.

June 1, 1993Human Reproduction

Hypersecretion of luteinizing hormone and ovarian steroids in women with recurrent early miscarriage

View Full Paper

Ask AI

Bookmark

Authors

HWHazel WatsonSt. Mary’s Hospital DKD. KiddySt. Mary's Hospital DHDiana Hamilton‐FairleyMedway NHS Foundation Trust

Discussion

Member takes

Implication

Case-control study reveals elevated luteinizing hormone and testosterone secretion in recurrent early miscarriage, suggesting endocrine disruptions impair oocyte or endometrial development.

Key Points

To evaluate cyclical patterns of gonadotrophin and sex steroid secretion in women with a history of recurrent early pregnancy loss.
Assessed serial blood and urine samples across the menstrual cycle in 21 women with recurrent early pregnancy loss and 10 multiparous controls.
Tracked ultrasound presence of polycystic ovaries alongside serial concentrations of serum LH, FSH, and follicular testosterone, as well as urinary LH, oestrone-3-glucuronide, and pregnanediol-3 alpha-glucuronide.
Abnormal LH secretion—manifested as elevated urinary LH excretion or a premature LH surge—was observed in 81% (17/21) of women with pregnancy loss compared to 10% (1/10) of controls.
Total urinary LH excretion across the cycle and mean follicular phase serum testosterone were significantly higher in women with pregnancy loss than in controls, with LH elevations most pronounced during the early luteal phase.
Urinary oestrone-3-glucuronide excretion was significantly elevated in the early luteal phase among women with pregnancy loss, while pregnanediol-3 alpha-glucuronide levels showed no significant difference between groups.

Cite This Study

Watson et al. (1993) studied this question.

synapsesocial.com/papers/6a93f91e4abec9dbc4d67c3a https://doi.org/10.1093/oxfordjournals.humrep.a138149

View Full Paper

Ask AI

Bookmark

June 1, 1993Human Reproduction

Hypersecretion of luteinizing hormone and ovarian steroids in women with recurrent early miscarriage

View Full Paper

Ask AI

Bookmark

Authors

HWHazel WatsonSt. Mary’s Hospital DKD. KiddySt. Mary's Hospital DHDiana Hamilton‐FairleyMedway NHS Foundation Trust

Discussion

Member takes

Implication

Case-control study reveals elevated luteinizing hormone and testosterone secretion in recurrent early miscarriage, suggesting endocrine disruptions impair oocyte or endometrial development.

Key Points

To evaluate cyclical patterns of gonadotrophin and sex steroid secretion in women with a history of recurrent early pregnancy loss.
Assessed serial blood and urine samples across the menstrual cycle in 21 women with recurrent early pregnancy loss and 10 multiparous controls.
Tracked ultrasound presence of polycystic ovaries alongside serial concentrations of serum LH, FSH, and follicular testosterone, as well as urinary LH, oestrone-3-glucuronide, and pregnanediol-3 alpha-glucuronide.
Abnormal LH secretion—manifested as elevated urinary LH excretion or a premature LH surge—was observed in 81% (17/21) of women with pregnancy loss compared to 10% (1/10) of controls.
Total urinary LH excretion across the cycle and mean follicular phase serum testosterone were significantly higher in women with pregnancy loss than in controls, with LH elevations most pronounced during the early luteal phase.
Urinary oestrone-3-glucuronide excretion was significantly elevated in the early luteal phase among women with pregnancy loss, while pregnanediol-3 alpha-glucuronide levels showed no significant difference between groups.

Cite This Study

Watson et al. (1993) studied this question.

synapsesocial.com/papers/6a93f91e4abec9dbc4d67c3a https://doi.org/10.1093/oxfordjournals.humrep.a138149

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark