Key result
Initial lytic therapy followed by anticoagulation was superior to anticoagulation alone for total venous recanalization and symptom resolution (80% vs 22%, P=0.018).
Why the study?
Does initial lytic therapy followed by anticoagulation improve total venous recanalization and symptom resolution compared to anticoagulation alone in patients with axillary-subclavian vein thrombosis?
Population
n=19 patients with axillary-subclavian vein thrombosis
Comparison
Initial lytic therapy followed by heparin and… vs Conventional treatment (heparin and warfarin)
Design
Cohort
Follow-up
mean 36 months
Authors
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May support lytic-first strategy in axillary-subclavian thrombosis; leaves open need for RCTs before practice change.
Cohort (n=19)
Does initial lytic therapy followed by anticoagulation improve total venous recanalization and symptom resolution compared to anticoagulation alone in patients with axillary-subclavian vein thrombosis?
Absolute Event Rate: 80% vs 22%
p-value: p=0.018
Lytic therapy followed by anticoagulation significantly improves venous recanalization and symptom resolution compared to anticoagulation alone in axillary-subclavian vein thrombosis, though at a substantially higher cost.
AbuRahma et al. (1996) conducted a cohort in Axillary-subclavian vein thrombosis (n=19). Initial lytic therapy followed by heparin and warfarin vs. Conventional treatment (heparin and warfarin) was evaluated on Total venous recanalization and symptom resolution (p=0.018). Initial lytic therapy followed by anticoagulation was superior to anticoagulation alone for total venous recanalization and symptom resolution (80% vs 22%, P=0.018).
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