Key result
Overexpression of the broad-spectrum antiviral protein ZAP reduced human LINE-1 retrotransposition in cell culture by over 75% compared to empty vector control.
Population
Human cell culture models (HEK 293T, HeLa, and human embryonal carcinoma 2102Ep cells)
Comparison
Overexpression or siRNA depletion of… vs Empty vector control or scrambled siRNA
Design
Preclinical
Authors
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No immediate clinical implications; leaves open ZAP's role in human retroelement-related disease.
The interferon-stimulated zinc-finger protein ZAP restricts human retrotransposition, highlighting its role in intrinsic cellular immunity against both viruses and endogenous retroelements.
Goodier et al. (2015) studied Human Retrotransposition. ZAP (Zinc-finger antiviral protein) overexpression vs. Empty vector control was evaluated on Cell culture retrotransposition (percentage of retrotransposition-positive cells). Overexpression of the broad-spectrum antiviral protein ZAP reduced human LINE-1 retrotransposition in cell culture by over 75% compared to empty vector control.
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