Key result
Chronic beta-adrenoreceptor antagonism significantly increased sino-aortic baroreflex sensitivity in hypertensive patients under 40 years of age, with no change after acute treatment or in older patients.
Why the study?
Does beta-adrenoreceptor antagonism alter sino-aortic baroreflex sensitivity and blood pressure in patients with essential hypertension?
Does beta-adrenoreceptor antagonism alter sino-aortic baroreflex sensitivity and blood pressure in patients with essential hypertension?
Chronic beta-blocker therapy increases baroreflex sensitivity in younger hypertensive patients, but this mechanism does not explain the blood pressure lowering effect.
Answers are grounded in this paper and cite their sources.
May enhance baroreflex sensitivity with chronic beta-blockade in young hypertensives only; hypothesis-generating and should not yet change practice.
Sensitivity of the sino-aortic baroreflex was investigated before and after acute (23 patients) and chronic (23 patients) beta-adrenoreceptor antagonism in patients with essential hypertension. 2. Sensitivity was inversely related to age (r = -0.60) and systolic blood pressure (r = -0.46); a positive relationship was noted between sensitivity and initial pulse intervals (r = 0.40). 3. Sensitivity increased significantly in patients less than 40 years of age after chronic treatment. No change occurred after acute treatment or in older patients treated chronically. 4. The fall in ambulatory intra-arterial blood pressure after chronic treatment was unrelated to alteration of baroreflex sensitivity.
No takes yet. Share an insight, caveat, or question.
Watson et al. (1979) studied essential hypertension (n=46). beta-adrenoreceptor antagonism vs. baseline (before treatment) was evaluated on Sensitivity of the sino-aortic baroreflex. Chronic beta-adrenoreceptor antagonism significantly increased sino-aortic baroreflex sensitivity in hypertensive patients under 40 years of age, with no change after acute treatment or in older patients.
Synapse has enriched 10 related papers. Consider them for comparative context: