Key result
Intense antecedent sympathetic stimulation diminished chronotropic responses to vagal and sympathetic test stimulations to 36.5% and 54.7% of prestimulation responses, respectively.
Population
Dogs anesthetized with alpha-chloralose
Comparison
Intense antecedent sympathetic stimulation vs Prestimulation responses (control values)
Design
Preclinical
Authors
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May guide research on neuropeptide Y in autonomic control; leaves open clinical relevance in humans.
Intense antecedent sympathetic stimulation causes prolonged prejunctional inhibition of cardiac sympathetic neurotransmission, likely mediated by neuropeptide Y.
Yang et al. (1993) studied this question. Intense sympathetic stimulation vs. Prestimulation responses was evaluated on Chronotropic responses to vagal and sympathetic test stimulations. Intense antecedent sympathetic stimulation diminished chronotropic responses to vagal and sympathetic test stimulations to 36.5% and 54.7% of prestimulation responses, respectively.
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