June 1, 1984Circulation Research

The phase-dependency of the cardiac chronotropic responses to vagal stimulation as a factor in sympathetic-vagal interactions.

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Population

Open-chest anesthetized dogs

Comparison

Repetitive bursts of vagal stimulation delivered… vs Trains of cardiac sympathetic nerve stimulation…

Design

Preclinical

Authors

TYTiantian YangJiaozuo University MLMatthew N. LevyTechnion – Israel Institute of Technology

Discussion

Member takes

Implication

Challenges accentuated antagonism in this model; leaves open translation to human autonomic therapies.

Structured PICO

Population

Open-chest anesthetized dogs

Intervention

Repetitive bursts of vagal stimulation delivered at specific times in the cardiac cycle (least or most effective time) combined with trains of cardiac sympathetic nerve stimulation at 2 and 4 Hz

Comparator

Trains of cardiac sympathetic nerve stimulation alone at 2 and 4 Hz

Outcome

Change in cardiac cycle length (positive chronotropic response)surrogate

The timing of vagal stimulation in the cardiac cycle determines whether it attenuates or paradoxically enhances the positive chronotropic response to sympathetic stimulation.

Cite This Study

Yang et al. (1984) studied this question.

synapsesocial.com/papers/6a7362da294a46cc7b2c2209 https://doi.org/10.1161/01.res.54.6.703

View Full Paper

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Bookmark

The phase-dependency of the cardiac chronotropic responses to vagal stimulation as a factor in sympathetic-vagal interactions.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The phase-dependency of the cardiac chronotropic responses to vagal stimulation as a factor in sympathetic-vagal interactions.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider