Key result
Baseline arterial vasopressin (beta 0.53; P=.041) and aldosterone (beta 0.56; P=.032) independently predicted left ventricular mass index in men who developed hypertension over 20 years.
Why the study?
Do baseline arterial vasopressin, aldosterone, and renin levels predict left ventricular mass in middle-aged men who develop hypertension over 20 years?
Cohort (n=56)
Do baseline arterial vasopressin, aldosterone, and renin levels predict left ventricular mass in middle-aged men who develop hypertension over 20 years?
Effect estimate: R(2)=0.85
p-value: p=.035
Baseline arterial vasopressin and aldosterone levels predict the development of left ventricular hypertrophy over 20 years in middle-aged men who develop hypertension.
Baseline vasopressin and aldosterone were associated with higher LVMI in men developing hypertension; hypothesis-generating and should not yet change practice.
Left ventricular (LV) hypertrophy is related to blood pressure level and neurohormonal factors. The authors previously demonstrated that arterial norepinephrine levels predict LV mass in middle-aged men who developed hypertension through 20 years. The aim of this 20-year prospective study was to investigate arterial vasopressin, aldosterone, and renin as long-term predictors of LV mass. Normotensives (n=17), subjects who developed hypertension (n=17), and sustained hypertensives (n=22) were compared at baseline (42 years) and at follow-up (62 years). There were no significant differences in baseline vasopressin, aldosterone, or renin levels. The group with sustained hypertension had more LV hypertrophy (P=.025) at follow-up. Among new hypertensives, multiple regression analysis demonstrated that baseline arterial vasopressin (beta-0.53; P=.041) and aldosterone (beta-0.56;P=.032) independently explained LV mass index (R(2)=0.85; P=.035). In conclusion, baseline arterial vasopressin and aldosterone, but not renin, appear to predict LV mass in middle-aged men who developed hypertension over a 20-year period.
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Strand et al. (2007) conducted a cohort in Hypertension (n=56). Baseline arterial vasopressin and aldosterone was evaluated on Left ventricular mass index (R(2)=0.85, p=.035). Baseline arterial vasopressin (beta 0.53; P=.041) and aldosterone (beta 0.56; P=.032) independently predicted left ventricular mass index in men who developed hypertension over 20 years.
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