Key result
An AII type 1 receptor antagonist (L-158,809) was more effective than an ACE inhibitor (captopril) in the prophylaxis of bone marrow transplantation nephropathy in rats.
Why the study?
Does an AT1 receptor antagonist prevent radiation-induced renal and lung injury in rats receiving total body irradiation and bone marrow transplantation?
Population
Rats receiving total body irradiation (TBI) followed by bone marrow transplantation (BMT)
Comparison
Angiotensin II type 1 receptor antagonist… vs ACE inhibitor (captopril) or no treatment
Design
Preclinical, randomized
Authors
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AT1 antagonism may offer superior prophylaxis versus ACE inhibition in rat radiation nephropathy models; hypothesis-generating for clinical translation.
RCT
randomized
Does an AT1 receptor antagonist prevent radiation-induced renal and lung injury in rats receiving total body irradiation and bone marrow transplantation?
AT1 receptor blockade is effective for the prophylaxis and treatment of radiation-induced renal and lung injury in a rat model, highlighting the role of the renin-angiotensin system in these injuries.
Johnathan Cohen (1998) conducted an RCT in radiation nephropathy and lung injury. AII type 1 (AT1) receptor antagonist (L-158,809) vs. ACE inhibitor (captopril) or no treatment was evaluated on renal function, histopathology and animal survival. An AII type 1 receptor antagonist (L-158,809) was more effective than an ACE inhibitor (captopril) in the prophylaxis of bone marrow transplantation nephropathy in rats.
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