The Effect of Pyridoxine, Phytate and Invert Sugar on Production of Plaque Acids in situ in the Monkey (M. fascicularis)

Gas-liquid chromatographic analyses were performed on acids in plaque from groups of monkeys fed a cariogenic diet in which sucrose was supplemented with pyridoxine, phytate or replaced by invert sugar while the controls received sucrose alone. Volatile acids were predominant in resting plaque. With the exception of isovalerate no intergroup differences in acid concentrations were significant. Within 1 h after sucrose application, significant intergroup differences in acid concentrations were observed in 5 of the 9 acids identified. Sucrose application was followed by a significant increase in lactic acid in plaque from each group, and increases in other acids occurred to a lesser extent. Total acid concentration increased in all groups, but was significant in only the control and invert sugar group.