Prolonged Survival of Skin and Tumor Allografts in Mice on High-Fat Diets: Brief Communication 2

The cancer-promoting effect of fat-enriched diets on mice has been known for several years. We investigated the effect of this type of diet supplemented with corn oil (200-400 ng/mouse daily), on two allograft models in the mouse, to determine whether an immunologic phenomenon occurred. Control mice were fed a standard diet. Skin grafts transplanted from DBA/2J mice to BALB/c mice and from C57BL/6J mice to C57BR mice survived significantly longer on recipients fed fat-enriched diets than on those fed the control diet. Similarly, allogeneic tumor grafts (6C3HED on C57BR and BALB/c mice, and dbrB on BALB/c mice) survived longer on groups fed the experimental diet.