January 1, 2010Climacteric
Endothelial function and cardiovascular risk stratification in menopausal women
Key result
Flow-mediated reactive hyperemia by digital tonometry (RHI) did not correlate with time past menopause, coronary arterial calcium, carotid intima-media thickness, or cholesterol levels.
Why the study?
Does digital tonometry (RHI) correlate with standard cardiovascular risk markers (CAC, CIMT) in recently menopausal women?
Population
102 non-diabetic Caucasian women asymptomatic for cardiovascular disease undergoing screening for the KEEPS…
Design
Cross-sectional
Authors
Discussion
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Implication
RHI should not yet inform CV risk assessment in menopausal women; leaves open whether it captures an independent vascular pathway.
Study Design
Type
Cross-Sectional (n=102)
Structured PICO
Does digital tonometry (RHI) correlate with standard cardiovascular risk markers (CAC, CIMT) in recently menopausal women?
P
Population
102 non-diabetic Caucasian women recently menopausal and asymptomatic for cardiovascular disease, evaluated for cardiovascular risk factors.
E
Exposure
Digital tonometry to measure flow-mediated reactive hyperemia (RHI)
O
Outcome
Correlation of RHI with carotid intima-media thickness (CIMT), coronary arterial calcium (CAC), and conventional risk factorssurrogate
In recently menopausal women, digital tonometry (RHI) varies widely and does not correlate with standard risk markers like CAC or CIMT, suggesting it may represent an independent component of cardiovascular risk.
Cite This Study
Mulvagh et al. (2010) conducted a cross-sectional in Recently menopausal women asymptomatic for cardiovascular disease (n=102). Flow-mediated reactive hyperemia by digital tonometry (RHI) was evaluated on Correlation of RHI with time past menopause, CAC, CIMT, total cholesterol, or LDL cholesterol. Flow-mediated reactive hyperemia by digital tonometry (RHI) did not correlate with time past menopause, coronary arterial calcium, carotid intima-media thickness, or cholesterol levels.