Key result
Treatment of vascular endothelial cells with angiogenic growth factors dramatically reduced caveolin-1 expression, an effect that was blocked by various angiogenesis inhibitors.
Population
Human umbilical vein endothelial cell line, ECV 304
Comparison
Angiogenic growth factors and angiogenesis… vs Untreated cells or cells treated with…
Design
Preclinical
Authors
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Should not change clinical practice; leaves open caveolin-1 as a mechanistic target in angiogenesis research.
Down-regulation of caveolin-1 by angiogenic growth factors may be a key step in endothelial cell proliferation, and this effect is blocked by angiogenesis inhibitors.
Liu et al. (1999) studied Angiogenesis. Angiogenic growth factors and angiogenesis inhibitors was evaluated on Caveolin-1 expression and caveolae formation. Treatment of vascular endothelial cells with angiogenic growth factors dramatically reduced caveolin-1 expression, an effect that was blocked by various angiogenesis inhibitors.
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