Key result
Transient overexpression of caveolin-1 in human endothelial cells dramatically inhibited proliferation by arresting cells in the G0/G1 phase and inhibiting VEGFR-2 and MAP kinase activity.
Population
Human endothelial cells
Design
Preclinical
Authors
Loading...
No clinical implications yet; leaves open caveolin-1 modulation as an angiogenesis target for further study.
Caveolin-1 acts as a negative regulator of endothelial cell proliferation by arresting the cell cycle at the G0/G1 phase, suggesting it as a potential target for controlling angiogenesis.
Fang et al. (2007) studied Angiogenesis. Adenovirus expressing caveolin-1 was evaluated on Endothelial cell proliferation and cell cycle progression. Transient overexpression of caveolin-1 in human endothelial cells dramatically inhibited proliferation by arresting cells in the G0/G1 phase and inhibiting VEGFR-2 and MAP kinase activity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: