Article1 September 1949THE PROGNOSIS AND TREATMENT OF HEPATIC INSUFFICIENCYCECIL JAMES WATSON, M.D., Ph.D., F.A.C.P.CECIL JAMES WATSON, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-3-405 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term "hepatic insufficiency" may be defined according to the usage of the individual observer of hepatic disease. There would probably be a uniform acceptance of the term for the comatose or disoriented patient with a severe hepatic disorder, such as diffuse necrosis or cirrhosis. This is the way in which the term is most often employed. Probably the majority of observers would agree, however, that it might also be used to apply to more serious clinical states associated with diffuse parenchymal hepatic disease, with jaundice and/or ascites, but without obvious mental depression or aberration. It is doubtful whether anyone...Bibliography1. HIPPOCRATES , Book of Prognostics, Med. Classics, 1938, iii, 43. Google Scholar2. PATEKPOST AJJ: Treatment of cirrhosis of the liver by a nutritious diet and supplements rich in vitamin B complex, Jr. Clin. Invest., 1941, xx, 481. CrossrefGoogle Scholar3. JONESVOLWILER CMW: An evaluation of various therapeutic programs in patients with acute fatty livers, Trans. Assoc. Am. Phys., 1947, lx, 232. Google Scholar4. BUCK RE: Observations on alcoholic fatty liver; the use of interval needle biopsy and liver function tests, Jr. Lab. and Clin. Med., 1948, xxxiii, 555. Google Scholar5. MACNIDER WD: The natural tendency of tissues to participate in a process of repair following injury and to establish some order of functional value, Proceedings Seventh Liver Injury Conference, Josiah Macy Jr., Foundation, 1948. Google Scholar6. ECKHARDTLEWISMURPHYBATCHELORDAVIDSON RDJHRLWHCS: Chemical, clinical, and immunological studies on the products of human plasma fractionation. XXXIX. Comparative studies on the nutritive value of orally and intravenously administered human serum albumin in man, Jr. Clin. Invest., 1948, xxvii, 119. CrossrefGoogle Scholar7. THORNARMSTRONGDAVENPORT GWSHVD: Chemical, clinical, and immunological studies on products of human plasma fractionation; use of salt-poor concentrated human serum albumin solution in treatment of hepatic cirrhosis, Jr. Clin. Invest., 1946, xxv, 304. CrossrefGoogle Scholar8. PATEKMARKINCOLCHERLOWELLEARLE AJHHADP: The effects of intravenous injection of concentrated human serum albumin upon blood plasma, ascites, and renal functions in three patients with cirrhosis of the liver, Jr. Clin. Invest., 1948, xxvi, 135. CrossrefGoogle Scholar9. SCHUMM O: Hämatin als pathologischer Bestandteil des Blutes, Ztschr. f. physiol. Chem., 1916, xcvii, 32. CrossrefGoogle Scholar10. BINGOLD K: Blutstoffwechsel. In: HIRSCHFELD, A., and HITTMAIR, A.: Handb. d. allg. Hämatol., Berlin, Urban and Schwarzenberg, 1, erste Hälfte, 601, 1932. Google Scholar11. VAN DEN BERGHKAMERLING AAAW: Levercirrhose met haemolytische anaemie en massale haematinaemie, Nederl. Tijd. v. Geneesk., 1934, lxxviii, 4432. Google Scholar12. DUESBERG R: Über die biologischen Beziehungen des Hämoglobins zu Bilirubin und Hämatin bei normalen und pathologischen Zuständen des Menschen, Arch. f. exper. Path. u. Pharm., 1934, clxxiv, 305. Google Scholar13. WATSON CJ: The pyrrol pigments with particular reference to normal and pathologic hemoglobin metabolism, Downey's Handb. of Hematol., Paul Hoeber & Co., New York, 1938, iv, 2447. Google Scholar14. PASSSCHWARTZWATSON IJSCJ: The conversion of hematin to bilirubin following intravenous administration in human subjects, Jr. Clin. Invest., 1945, xxv, 283. CrossrefGoogle Scholar15. WATSON CJ: Cirrhosis of the liver: Clinical aspects with particular reference to liver function tests. Liver Symposium, Am. Jr. Clin. Path., 1944, xiv, 127. Google Scholar16. Homologous serum jaundice. Memorandum prepared by medical officers of the Ministry of Health, Lancet, 1943, i, 83. Google Scholar17. Catarrhal and human serum jaundice, Editorial, Jr. Am. Med. Assoc., 1943, cxxii, 746. Google Scholar18. BARKERCAPPS MHRB: Acute infectious hepatitis in the Mediterranean Theater, Jr. Am. Med. Assoc., 1945, cxxviii, 997. CrossrefGoogle Scholar19. NAUNYNUMBER DF: Erkrankungen der Leber, der Gallenwege und der Pankreas, Handb. d. inn. Med., Bd. III, Teil 2, 1926, J. Springer, Berlin, p. 100. Google Scholar20. ROYERSOLARI MAV: Cholangiography performed with the help of peritoneoscopy, Gastroenterology, 1947, viii, 586. Google Scholar21. HORAN T: Personal communication. Google Scholar22. FAGINTHOMPSON DFM: Cirrhosis of the liver, an analysis of 71 cases, Ann. Int. Med., 1944, xxi, 285. Google Scholar23. EPPINGER H (a) : Die Leberkrankheiten. Allgemeine und spezielle Pathologie und Therapie der Leber, 1937, Julius Springer, Wien. (b) WEIR, J. F.: Atrophy and necrosis of the liver without jaundice, Ann. Int. Med., 1939, xii, 1845-1854. (c) SATKE, O.: Acute atrophy of liver without icterus, Wien. klin. Wchnschr., 1940, liii, 145. (d) LAWRENCE, J. S.: Subacute necrosis of liver without icterus, Lancet, 1946, ii, 41. Google Scholar24. WATSON CJ: Some newer concepts of the natural derivatives of hemoglobin. I. General considerations. II. The serum bilirubin and bilirubinuria. III. The erythrocyte protoporphyrin, Blood, Jr. Hematol., 1946, i, 99. Google Scholar25. ADAMSON JD: The liver as the organ of sanguification, Canad. Med. Assoc. Jr., 1928, xviii, 147. Google Scholar26. WATSONGREENBERG CJA: Certain effects of salt poor human albumin in cases of hepatic disease, Am. Jr. Med. Sci., 1949, ccxvii, 651. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Delivered in part as a morning lecture, Twenty-Ninth Annual Session, American College of Physicians, San Francisco, April 23, 1948.From the Department of Medicine, University of Minnesota Hospital, Minneapolis, Minn.Aided by grants from the Dietene Corporation, Minneapolis, and the Medical Research Fund of the Graduate School, University of Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEncephalopathy Due to Mercaptans and PhenolsImpaired metabolism of methionine in severe liver diseases II. Clinical and experimental studies on role of impaired methionine metabolism in pathogenesis of hepatic encephalopathyBlood methanethiol in alcoholic liver disease with and without hepatic encephalopathy.Plasma and urinary amino acids in laennec's cirrhosisEnzymic methylation of foreign sulfhydryl compoundsBlood AmmoniaClinical diagnosis of liver diseaseEinige Grundprobleme der Störung der Leberfunktion bei der Hepatitis und ihren FolgezuständenHepatic ComaThe failure of monosodium glutamate in the treatment of hepatic comaMethionine and Hepatic CirrhosisGLUTAMIC ACID IN HEPATIC COMAFŒTOR HEPATICUSThe Treatment of a Patient in Hepatic Coma with Intravenous Sodium Glutamate and ActhDie Krankheiten der Leber und der GallenwegeADRENAL CORTEX IN LIVER DISEASE*JOHN JOSEPH WEBSTER, M.D., F.A.C.P. 1 September 1949Volume 31, Issue 3Page: 405-423KeywordsAscitesCirrhosisComaGraduate medical educationHospital medicineNecrosisResearch funding ePublished: 1 December 2008 Issue Published: 1 September 1949 PDF downloadLoading ...
No takes yet. Share an insight, caveat, or question.
C J WATSON (1949) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: