Key result
Norovirus infection was detected in 3.12% of patients hospitalized with acute gastroenteritis in Kolkata, India, with NVGII strains accounting for 92.3% of the positive cases.
Cross-Sectional (n=2,495)
No
Norovirus is a significant viral etiological agent of acute gastroenteritis in both children and adults in Kolkata, India, characterized by a high genetic diversity of circulating NVGII strains.
Supports norovirus surveillance in Indian hospitals; leaves open impact on diagnostics or prevention strategies.
Faecal specimens of diarrhoea cases (n=2495, collected between November 2007 and October 2009) from Infectious Diseases and Beliaghata General (ID&BG) Hospital, Kolkata, India, were screened by RT-PCR using specific primers targeting region C of the capsid gene of noroviruses (NoVs) to determine the seasonal distribution and clinical characteristics of NoVs associated with diarrhoea. NoV infection was detected in 78 cases, mostly in children aged <2 years. In 22/78 positive cases, the virus was detected as the sole agent; others were as mixed infections with other enteric pathogens. Sequencing of NVGII strains showed clustering with GII.4 NoVs followed by GII.13 and GII.6 NoVs. Clinical characteristics of the diarrhoeic children and adults in Kolkata indicated that NoV infections were detected throughout the year and were associated with a mild degree of dehydration.
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Nataraju et al. (2010) conducted a cross-sectional in Acute gastroenteritis (n=2,495). Norovirus infection was evaluated on Prevalence of Norovirus infection. Norovirus infection was detected in 3.12% of patients hospitalized with acute gastroenteritis in Kolkata, India, with NVGII strains accounting for 92.3% of the positive cases.
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