Key result
Norovirus genogroup II infection was found in 9.9% of hospitalized children with diarrhea and was associated with more severe episodes (median Vesikari score 13 vs 10; P=0.002).
Observational (n=282)
No
Absolute Event Rate: 13% vs 10%
p-value: p=0.002
Norovirus GII is an important cause of severe gastroenteritis in hospitalized children under 5 in South India.
Norovirus GII may flag higher-risk cases among hospitalized children; leaves open prospective studies before guiding testing or prevention.
The distribution of norovirus (NoV) genogroup II in children < 5 years of age admitted to a south Indian hospital with diarrhea was investigated. Viral RNA extracted from 282 stool samples were screened for NoV GII and positive amplicons sequenced. Twenty-eight (9.9%) had NoV GII infection with a median age of 6 months, with more severe episodes of diarrhea among infected (median Vesikari score 13, interquartile range [IQR] 10-15) than children without infection (median score 10, IQR 8-13, P = 0.002). The study documents NoV GII infections as an important cause of gastroenteritis and the genetic diversity of circulating strains.
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Menon et al. (2013) conducted an observational in Diarrhea (n=282). Norovirus genogroup II infection vs. Children without infection was evaluated on Severity of diarrhea (Vesikari score) (p=0.002). Norovirus genogroup II infection was found in 9.9% of hospitalized children with diarrhea and was associated with more severe episodes (median Vesikari score 13 vs 10; P=0.002).
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