Key result
Induced metabolic acidosis caused extremely high ventilatory increases during acute exercise, driven by increased tidal volumes, and markedly prolonged recovery times for ventilation.
Why the study?
Does induced metabolic acidosis alter the respiratory response (ventilation, carbon dioxide output, and oxygen uptake) to acute exercise?
Population
Subjects undergoing acute exercise (specific demographics and sample size not stated in abstract)
Comparison
Induced marked metabolic acidosis by means of… vs Baseline state before inducing metabolic acidosis
Design
Other
Authors
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Exaggerated ventilatory responses with acidosis may occur in cardiopulmonary disease; leaves open causal role and requires patient studies.
Does induced metabolic acidosis alter the respiratory response (ventilation, carbon dioxide output, and oxygen uptake) to acute exercise?
Induced metabolic acidosis produces an exaggerated ventilatory response and prolonged recovery during acute exercise, a pattern similar to that observed in patients with cardiac or cardiopulmonary disease.
H. E. Refsum (1961) studied this question. Induced metabolic acidosis (ammonium chloride) vs. Baseline (before induced acidosis) was evaluated on Ventilation, carbon dioxide output and oxygen uptake. Induced metabolic acidosis caused extremely high ventilatory increases during acute exercise, driven by increased tidal volumes, and markedly prolonged recovery times for ventilation.
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