Key result
Adipocyte hypertrophy, rather than obesity per se, is a strong predictor of type 2 diabetes and is linked to metabolic and cardiovascular diseases.
Adipocyte hypertrophy may refine T2D risk stratification beyond BMI; leaves open causal cardiovascular links pending validation.
Obesity rates continue to rise worldwide, with a concomitant increase in co-morbidities, including metabolic disease, cardiovascular disease and cancer. The onset of obesity is most often characterized by an increase in the size of white adipose tissue fat cells (adipocyte hypertrophy) and secondary to this by adipocyte hyperplasia. Adipocyte hypertrophy is strongly linked to metabolic and cardiovascular disease with hypertrophy and not obesity per se, a predictor of type 2 diabetes.1 The contribution of visceral adipose tissue to these pathologies is even more pronounced.
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Li et al. (2022) conducted a review in Obesity and adipocyte hypertrophy. Adipocyte hypertrophy was evaluated. Adipocyte hypertrophy, rather than obesity per se, is a strong predictor of type 2 diabetes and is linked to metabolic and cardiovascular diseases.
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