Key result
Parietal shear stress and local hemodynamics in coronary artery bifurcations are key factors in the development and progression of atherosclerotic plaques.
Local hemodynamics, particularly parietal shear stress, play a key role in the development and progression of atherosclerotic plaques at coronary artery bifurcations.
Local hemodynamics at bifurcations may influence plaque formation; leaves open whether shear stress assessment refines risk stratification.
Formation of atherosclerotic plaque in the coronary arteries is complex and multifactorial process, depending not only on conventional risk factors for cardiovascular diseases, but also on the features of local hemodynamics. Atherosclerotic plaques often form in the bifurcation area, where blood flow is uneven. In these settings, parietal shear stress becomes a key factor in the development, spread and progression of atherosclerotic plaque. In addition, a number of factors, such as the individual geometry of bifurcation, coronary stenting, and implantation technique can significantly affect the shear stress values, thus, affect the pathophysiology of coronary atherosclerosis.
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Khelimsky et al. (2020) conducted a review in Coronary atherosclerosis. Local hemodynamics and parietal shear stress was evaluated. Parietal shear stress and local hemodynamics in coronary artery bifurcations are key factors in the development and progression of atherosclerotic plaques.
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