Key result
Numerical simulations of coronary artery bifurcations revealed that the curvature of the walls connecting the vessels plays an unexpectedly important role in flow dynamics and plaque deposition.
Why the study?
Coronary plaque deposition is influenced by flow dynamics, where the topology of arterial bifurcations plays a crucial role.
Computational modeling demonstrates that the curvature of walls at coronary bifurcations significantly influences flow dynamics and plaque deposition.
Wall curvature merits inclusion in bifurcation flow models; leaves open validation against clinical plaque progression.
The risk of cardiovascular diseases is determined by the deposition of plaque in the coronary arteries. The areas of plaque deposition are also controlled by the flow dynamics and, for this, the topology of the arterial bifurcations has shown to be crucial. We present a detailed analysis of different topologies at the bifurcation based on numerical simulations of a mathematical model. Different diameters of the involved vessels as well as angle between them are analyzed. Unexpectedly, the curvature of the walls connecting the vessels is observed to play an important role.
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Otero-Cacho et al. (2022) studied Coronary artery plaque formation. Topology of arterial bifurcations (diameters, angles, curvature) was evaluated on Flow dynamics and plaque deposition. Numerical simulations of coronary artery bifurcations revealed that the curvature of the walls connecting the vessels plays an unexpectedly important role in flow dynamics and plaque deposition.
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