Answers are grounded in this paper and cite their sources.
The direct functionalization of non-activated C-H bonds, especially in an enantioselective manner, requires metal catalysts equipped with ligands with specifically designed properties. Examples for asymmetric C(sp(2))-H and C(sp(3))-H functionalizations using palladium- and rhodium catalysts are shown. This work was rewarded by the 2012 Werner Prize of the Swiss Chemical Society.
No takes yet. Share an insight, caveat, or question.
Nicolai Cramer (2012) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: