Key result
Recombinant human growth hormone administration progressively improved height pattern in children with hypochondroplasia at 12 months and 36 months (p < 0.0001).
Why the study?
Does recombinant human growth hormone improve height outcomes in short children with hypochondroplasia?
Meta-Analysis (n=113)
Does recombinant human growth hormone improve height outcomes in short children with hypochondroplasia?
Recombinant human growth hormone treatment progressively improves short-term height outcomes in children with hypochondroplasia up to 36 months.
Answers are grounded in this paper and cite their sources.
Supports rhGH consideration for hypochondroplasia; extends meta-analytic evidence for sustained short-term height gains.
Hypochondroplasia (HCH) is a genetic skeletal dysplasia, characterized by rhizomelic short height (Ht) with facial dysmorphology and lumbar hyperlordosis. Albeit there are concerns that HCH children may not achieve optimal long-term outcome in response to recombinant human growth hormone (rhGH), anecdotal experiences suggested at least short-term Ht improvement. After thorough search of published studies, meta-analysis of rhGH use in HCH children was performed. In 113 HCH children, rhGH administration (median 0.25 mg/kg/week) progressively improved Ht pattern with 12 months catch-up growth (p < 0.0001). Then, Ht improvement resulted constant until 36 months (p < 0.0001), but stature remained subnormal. While bone age chronologically progressed, no serious adverse events were reported. In conclusion, our meta-analysis indicates that rhGH treatment progressively improved Ht outcome of HCH subjects.
No takes yet. Share an insight, caveat, or question.
Massart et al. (2015) conducted a meta-analysis in Hypochondroplasia (n=113). Recombinant human growth hormone (rhGH) was evaluated on Height pattern improvement (p=<0.0001). Recombinant human growth hormone administration progressively improved height pattern in children with hypochondroplasia at 12 months and 36 months (p < 0.0001).
Synapse has enriched 10 related papers. Consider them for comparative context: